Avacta Group Plc Snapshot
Our mission is to shape the future of medicine by providing powerful reagents for research and diagnostics, and by developing safe and efficacious medicines.
At Avacta we have developed Affimer® technology, an engineered alternative to antibodies. Based on a small protein, Affimer technology can be quickly developed to bind with high specificity and affinity to a wide range of targets.
Affimer proteins can be developed as therapeutic molecules and can be used in a wide range of other life sciences applications in research and diagnostics.
"What really excites me, and drives the company, is the opportunity to change the way life scientists explore the complexity of the proteome and the myriad of interactions that define us as humans."
CHIEF EXECUTIVE OFFICER, AVACTA
Reagents & Diagnostics
Affimer reagents are ideal tools for use in a wide variety of diagnostic and research applications. With a rapid development timeline Affimer reagents represent a quick solution to rapidly unfolding research needs and ever growing needs for quality diagnostic reagents with consistent supplies. Custom Affimer solutions are available to meet your Diagnostic and Research needs.
Affimer technology offers highly specific target recognition in a variety of complex samples, while retaining both chemical and thermal stability. Affimer molecules offer flexibility in formatting via both genetic and chemical means. A single strategic cysteine residue addition allows for site specific functionalisation with enzymes, dyes, fluors, or immobilization onto a variety of surfaces. In addition to classical chemical methods of modification, we are also able to express genetic modifications to optimise performance (GFP, carrier proteins, and even multimers).
We develop highly specific, reproducible, and stable tools for use in point of care (POC) tests, research assays and immunoassays, and bioprocessing and separations from complex matrices.
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Affimer reagents and therapeutics are a class of non-antibody binding proteins that have been engineered for a wide range of applications where antibodies and aptamers have limitations. They can be used to detect difficult targets, can easily be formatted for a wide range of applications and can be easily and cost effectively manufactured.
What is an Affimer?
Two Affimer scaffolds, based on similar protein conformations, have been developed. The first is of human origin, based on the naturally occurring human protease inhibitor Stefin A, and is ideal for therapeutic applications. The second is based on a consensus sequence of Cystatin A from a number of plant species and is ideal for use in reagents and diagnostics.
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