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VERONA PHARMA PLC - Data on RPL554 to be presented at ERS Congress

Verona Pharma plc

("" or the "Company")Verona Pharma

New clinical data on RPL554 to be presented at the 2016ERS International Congress

Detailed data from Phase 2a “add-on” trial as “LATE-BREAKING abstract”

– (AIM: VRP.L), the drug development company focused on first-in-class medicines to treat respiratory diseases, today announces that it will present three abstracts at the (ERS) 2016 in between 3-7 September. The abstracts will cover clinical data related to the Company’s lead drug, RPL554, a novel inhaled dual PDE3/PDE4 inhibitor with both bronchodilator and anti-inflammatory properties. RPL554 is currently in development as a nebulised maintenance treatment for chronic obstructive pulmonary disease (COPD) patients with moderate to severe disease and as a treatment for acute exacerbations in COPD patients in a hospital or home-care setting., Cardiff30 August 2016Verona Pharma plcEuropean Respiratory SocietyInternational CongressLondon, UK

Detailed results from the Company’s Phase 2a “add-on” trial, where RPL554 produced a statistically and clinically significant additional bronchodilation on top of standard of care bronchodilators in COPD patients, will be presented for the first time in an oral presentation, by Professor from the Medicines Evaluation Unit, , during a late-breaker session on Monday, , at 11:00 in Room C.Dave SinghUniversity of Manchester5 September 2016

All three abstracts presented at ERS support Verona Pharma’s view that RPL554 could become an important, novel and complementary inhaled medicine for the treatment of respiratory diseases such as COPD, asthma and cystic fibrosis. In summary, the detailed data supports previously announced analysis of headline data which identified:

All abstracts and details on timings can be accessed through the ERS website:http://erscongress.org/

The title, timing and location of the abstract presentations are as follows:

   

   

-ENDS-

AboutVerona Pharma

is a -based clinical stage biotech company focused on the development of innovative prescription medicines to treat respiratory diseases with significant unmet medical needs, such as chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis.Verona Pharma plcUK

lead drug, RPL554, is a first-in-class drug currently in Phase 2 trials as a nebulised maintenance treatment for COPD patients with moderate to severe disease and possibly as a treatment of acute exacerbations of COPD in the hospital setting. The drug is a dual phosphodiesterase (PDE) 3/4 inhibitor and therefore has both bronchodilator and anti-inflammatory effects, which are essential to the improvement of patients with COPD and asthma.Verona Pharma's

is also building a broader portfolio of RPL554-containing products to maximise its benefit to patients and its value. This includes the very significant markets for COPD and asthma maintenance therapy. The Company is also exploring the potential of the drug in different diseases, such as cystic fibrosis, where it is in pre-clinical testing and has received a Venture and Innovation Award from the .Verona PharmaCystic Fibrosis Trust

About ERS

(ERS; ) is an international organisation that brings together physicians, healthcare professionals, scientists and other experts working in respiratory medicine. It is one of the leading medical organisations in the respiratory field, with a growing membership representing over 140 countries worldwide.The European Respiratory Societywww.ersnet.org

ERS’s mission is to promote lung health in order to alleviate suffering from disease and drive standards for respiratory medicine globally. Science, education and advocacy are at the core of everything it does.

THE 26th will take place at London’s ExCeL Centre and will host the world's largest and most influential meeting for respiratory physicians, scientists and allied health professionals. The Congress Scientific programme will present the best in science and educational sessions from distinguished researchers from across the globe. It will cover key topics in respiratory medicine from across the spectrum of disease areas including TB, lung cancer, pneumonia, cystic fibrosis, COPD and asthma amongst others.ERS International Congress

Further information on the congress can be accessed via the following weblink:http://erscongress.org/

For further information, please contact:

--  Profound and sustained bronchodilation in healthy volunteers, COPD
        patients and asthmatics;
    --  Comparable bronchodilation to high dose nebulised salbutamol (a standard
        of care treatment) in asthmatics with fewer systemic effects; and
    --  Statistically and clinically significant improvements in lung function
        when administered as “add-on” treatment to existing standard of care
        bronchodilators in COPD patients.
Abstract Number: 750050

Authors:         , , 

Title:           LATE-BREAKING ABSTRACT: The novel inhaled dual PDE3/4
                 Inhibitor, RPL554, produces significant additional improvements
                 in lung function when administered on top of existing standard
                 of care in COPD patients

Day/Date:        

Location:        Room C

Time:            10:45 - 12:45

Session:         Late-breaking topics in airways disease

Session Type:    Oral PresentationD. SinghK.H. Abbott-BannerK. NewmanMONDAY, September 5, 2016
Abstract Number: 851700

Authors:         , , 

Title:           RPL554, an inhaled PDE3/4 inhibitor, causes profound and
                 sustained bronchodilation in healthy volunteers and COPD
                 patients

Day/Date:        

Location:        T-21

Time:            12:50 - 14:40

Session:         Novel avenues in the treatment of COPD

Session Type:    Thematic Poster SessionD. SinghK.H. Abbott-BannerK. NewmanTUESDAY, September 6, 2016
Abstract Number: 853133

Authors:         L. Bjermer, , , 

Title:           RPL554, an inhaled PDE3/4 inhibitor, causes comparable
                 bronchodilation to high dose nebulised salbutamol in asthmatics
                 with fewer systemic effects

Day/Date:        

Location:        Room ICC Capital Suite 8.

Time:            8:30 - 10:30

Session:         Novel mechanisms and treatment modalities in asthma

Session Type:    Poster DiscussionJ. StewartK. Abbott-BannerK. NewmanWEDNESDAY, September 7, 2016
Tel: +44 (0)20 3283 4200

, CEO

N+1 Singer                          Tel: +44 (0)20 7496 3000

 / 

FTI Consulting                      Tel: +44 (0)20 3727 1000

 /  /Verona Pharma plcJan-Anders KarlssonAubrey PowellJen BoorerSimon ConwayStephanie CuthbertNatalie Garland-Collins
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