Proactive Investors - Run By Investors For Investors

AVEO Pharmaceuticals reports smaller tumors in Phase 2 study of drug for renal cell cancer

The most common complaints for the drug in the study was hypertension
Cancer cells.
AVEO is a biopharmaceutical company that develops treatments for renal cell cancers

AVEO Pharmaceuticals (NASDAQ:AVEO) and EUSA Pharma said the Phase 2 portion of a study evaluating a treatment for renal cell carcinoma, the most common type of kidney cancer, showed a total of 72% of patients reported around a quarter shrinkage in their tumors and that a majority of patients kept their disease under control for up to 48 weeks.

The Phase 2 portion of the study was designed to assess the safety, tolerability, and anti-tumor activity of the full dose and schedule of PO tivozanib in combination with nivolumab developed by Bristol-Myers Squibb (NYSE:BMY). The combination was generally well tolerated, the company said. Treatment-related Grade 3/4 adverse events occurred in 60% of patients, the most common of which was hypertension.

“With high and durable tumor shrinkage rates for the combination of tivozanib and nivolumab, including a complete response, coupled with a favorable tolerability profile and nearly all patients having disease control, the (TiNivo)  study continues to underscore a compelling rationale ... in immuno-oncology combinations,” Doctor Bernard Escudier, the ex-chairman of the Genitourinary Oncology Committee, Gustave Roussy, and lead investigator of the study, said.

He added that the ability to give an inhibitor and immuno-oncology agent "at full dose and strength could serve to deliver both improved outcomes and an improved patient experience."

Shares of AVEO though were down 8.6% to $2.275 in early trade.

READ: AVEO Pharmaceuticals gives up gains as put options weigh on shares

“We continue to build out a clinical strategy for studying such combinations, and look forward to outlining our plans following reporting of topline data ... which is expected in the mid-fourth quarter,” said Michael Bailey, president and CEO of AVEO.

Tivozanib is an oral, once-daily, vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) and approved for the treatment of adult patients with advanced renal cell carcinoma (RCC) in the European Union plus Norway and Iceland.

AVEO is a biopharmaceutical company dedicated to advancing a broad portfolio of targeted medicines for oncology and other areas of unmet medical need.

The company’s strategy is to retain North American rights to its oncology portfolio while securing partners in development and commercialization outside of North America. AVEO is seeking to develop and commercialize its lead candidate tivozanib in North America as a treatment for advanced or metastatic renal cell carcinoma.

The company is based in Cambridge, Massachusetts.

Reporting by Rene Pastor, contactable on [email protected]

View full AVEO profile View Profile

AVEO Pharmaceuticals Timeline

Related Articles

Nemaura Medical Inc CEO Dr Faz Chowdhury
November 05 2018
The medtech company is eying explosive growth with sugarBEAT, on the cusp of launching in the UK, followed by the rest of Europe in 2018
September 27 2018
WideCells has undertaken a review of the business to deliver a strategy that will generate revenue, reduce overheads and achieve profitability
PT exercises
December 19 2018
The Californian company is a bet on an industry that is in need of transformation
Copyright ©, 2019. All Rights Reserved - Proactive Investors North America Inc., Proactive Investors LLC

Market Indices, Commodities and Regulatory News Headlines copyright © Morningstar. Data delayed 15 minutes unless otherwise indicated. Terms of use