logo-loader
Hemispherx Biopharma Inc

Hemispherx Biopharma's cancer drug Ampligen to be used in new oncology study

Roswell Park Comprehensive Cancer Center will kick off an oncology study evaluating Ampligen along with Merck's blockbuster cancer drug Keytruda

cancerous cells
Investors applauded the news, sending Hemispherx shares up 18.3% to $0.23

Hemispherx Biopharma (NYSE American:HEB) reports that Roswell Park Comprehensive Cancer Center will kick off an oncology study to evaluate its experimental drug Ampligen along with the Merck & Co (NYSE:MRK) blockbuster cancer drug Keytruda in patients with metastatic triple-negative breast cancer.

The trial will enroll at least six participants and be conducted by Drs. Mateusz Opyrchal and Pawel Kalinski at Roswell Park, a National Cancer Institute-designated comprehensive cancer center in Buffalo, New York.

The study will assess how well Ampligen-based chemokine modulation therapy works when given prior to Keytruda in treating patients with triple-negative breast cancer that has spread to other places in the body.

“At Team Hemispherx, we are determined to pursue an aggressive R&D program focused on improved immune therapies for lethal malignancies, and we are grateful for the support and attention we are getting from big pharma and these major research institutions,” said Hemispherx CEO Thomas Equels in a statement.

READ: Hemispherx Biopharma started with a Buy rating at Ascendiant Capital Markets

Drugs used in this chemokine modulation therapy – celecoxib, recombinant interferon alfa-2b and Ampligen – work by boosting cancer immune responses that already exist by either blocking inhibitory molecules or by activating stimulatory molecules.

The clinical trial aims to determine whether chemokine modulation therapy before Keytruda will work better than Keytruda alone in patients with metastatic triple-negative breast cancer by altering the tumor microenvironment to favor immune rejection.

Investors applauded news of the trial, sending Hemispherx shares up 18.3% to $0.23 in Tuesday’s afternoon trading session.

READ: Biotech companies dominate at Dawson James Securities Small Cap Growth Conference

The study will assess patients with metastatic triple-negative breast cancer who will undergo a pre-treatment biopsy. Participants then receive two cycles of chemokine modulation therapy followed by an additional biopsy. After the biopsy and chemokine modulation therapy, participants will receive Keytruda every three weeks for two cycles.

A second clinical trial combining Ampligen with Keytruda to treat 40 patients with ovarian cancer is set to launch later this month at the University of Pittsburgh. It will be an important and more extensive test of Ampligen as an immune system primer that can change cold tumors into hot tumors and make the formerly cold tumors more responsive to Keytruda, according to the company.

“Relevant preclinical experiments in several types of solid tumors and conducted at different major US cancer research centers support the proposition that Ampligen can change the micro-environment of tumors so as to create a robust and significant positive synergy with check point blockade therapies,” explained Equels.

Hemispherx is making great strides in using its therapy Ampligen as an immuno-oncology agent to fight multiple types of cancer.

The company is currently supporting the evaluation of Ampligen’s use in fighting eight solid tumors (urothelial carcinoma, renal cell carcinoma, melanoma, triple-negative breast, colorectal, ovarian, non-small cell lung and pancreatic carcinomas) as part of a number of separate clinical studies at major research institutions.

Contact Ellen Kelleher at [email protected]

Quick facts: Hemispherx Biopharma Inc

Price: $1.86

Market: NYSE
Market Cap: $4.12 m
Follow

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events

NO INVESTMENT ADVICE

The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of Hemispherx Biopharma Inc named herein, including the promotion by the Company of Hemispherx Biopharma Inc in any Content on the Site, the...

FOR OUR FULL DISCLAIMER CLICK HERE

Watch

Hemispherx Biopharma makes progress with Phase 2 clinical trial to treat...

Hemispherx Biopharma Inc (NYSEAMERICAN:HEB) CEO Thomas Equels tells Proactive Investors the biopharma has taken a key step forward in its Phase 2 clinical trial after it announced that the first patient has been treated with its flagship drug Ampligen. Equels says this study looks at the...

on 06/20/2019

3 min read