Proactive Investors - Run By Investors For Investors

Humanigen unveils promising results from Ifabotuzumab Phase I study at the American Association for Cancer Research's annual meeting

Ifabotuzumab shows potential in attacking brain tumors by killing the stromal cells that protect them and the vasculature that feeds them without killing normal cells
cancerous cells
Humanigen, which is based in Burlingame, California, is developing monoclonal antibodies to improve CAR-T cancer therapies and oncology treatments

Humanigen (OTCMKTS:HGEN) told investors Monday that the promising preliminary results from a Phase 1 trial evaluating its flagship cancer treatment ifabotuzumab in patients with recurrent brain cancer will be showcased at the American Association for Cancer Research’s annual meeting in Atlanta, Georgia (March 29-April 3).

Its Phase 1 study shows the potential of this anti-EphA3 monoclonal antibody to attack tumors by killing the stromal cells that protect them and the vasculature that feeds them without killing normal cells. 

Indeed, ifabotuzumab’s impact on tumor vasculature provides evidence that targeting EphA3-expressing tumor neovasculature is a viable therapy for fighting solid tumors.

READ: Humanigen pins hopes on monoclonal antibody treatment of cancer therapy's side effects

EphA3 is a tumor-restricted antigen expressed in the tumor vasculature of aggressive brain cancers. It also surfaces in the tumor vasculature and tumor stroma of colon, lung, kidney and bladder tumors, as well as melanoma.

“By specifically targeting the tumor stem cells, stromal cells and neovasculature, we believe ifabotuzumab has the potential to emerge as a next-generation oncology therapy for a range of solid tumors,” said Dr. Cameron Durrant, CEO of Humanigen, in a statement.

READ: Humanigen CEO optimistic on drug candidate after pulling company from the brink

Research for the Phase 1 study was led by Drs Andrew Scott and Hui Gan of the Olivia Newton-John Cancer Research Institute in Heidelberg, Victoria, Australia. And its preliminary results include data from four patients who have been enrolled so far.

As part of the trial, positron emission tomography (PET) imaging showed that ifabotuzumab accumulated at the site of the tumor in all patients treated and didn’t affect normal brain tissue.

The preliminary results are consistent with a preclinical study published recently in the journal ‘Cancers’ by doctors Bryan Day & Andrew Boyd from the QIMR Berghofer Medical Research Institute in Brisbane, Australia, in which they showed that the EphA3 receptor is an attractive tumor-specific target for tumors of the brain and other solid cancers.

Humanigen, which is based in Burlingame, California, is developing monoclonal antibodies to improve CAR-T cancer therapies and oncology treatments. Its key drug candidate is lenzilumab, a recombinant monoclonal antibody that neutralizes a substance that promotes growth of white blood cells but is also tied to inflammations that can occur during CAR-T therapies and lead to side effects.

Humanigen shares closed at $1.35 on Friday.

Contact Ellen Kelleher at [email protected]

View full HGEN profile View Profile

Humanigen Inc Timeline

Related Articles

cancerous cells
April 15 2019
The company’s cancer treatment is based on work undertaken by John Beard, a professor of embryology at Edinburgh University nearly 100 years ago
seeds in a bowl
March 07 2019
The Vancouver company is developing Omega-3 products as oil, powder or emulsion to be used as food additives
Challenge trials can speed up vaccine development
May 30 2019
The challenge trial charts the entire disease life cycle from healthy to sick and back to health.
Copyright © Proactiveinvestors.com, 2019. All Rights Reserved - Proactive Investors North America Inc., Proactive Investors LLC

Market Indices, Commodities and Regulatory News Headlines copyright © Morningstar. Data delayed 15 minutes unless otherwise indicated. Terms of use